Association of Statin Use With All-Cause and CV Mortality in US Veterans 75 Years and Older

JAMA.2020;324(1):68-78. doi:10.1001/jama.2020.7848

Ariela R. Orkaby, MD, MPH1,2,3;Jane A. Driver, MD, MPH1,2,3;Yuk-Lam Ho, MPH2;et al

Key Points

Question Among US veterans 75 years and older and free of atherosclerotic cardiovascular disease at baseline, is statin use associated with lower risk of mortality?

Findings In this retrospective cohort study that used propensity score overlap weighting and included 326 981 participants, statin use, compared with no statin use, was significantly associated with a lower risk of all-cause and cardiovascular mortality (hazard ratios, 0.75 and 0.80, respectively).

Meaning Among older US veterans without atherosclerotic cardiovascular disease at baseline, statin therapy was significantly associated with a lower risk of mortality.