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COVID-19 and Postinfection ImmunityLimited Evidence, Many Remaining Questions

JAMA.Published online May 11, 2020. doi:10.1001/jama.2020.7869

In the absence of effective treatment or biomedical prevention, efforts to control the coronavirus disease 2019 (COVID-19) pandemic have relied on nonpharmaceutical interventions such as personal preventive actions (eg, handwashing, face covers), environmental cleaning, physical distancing, stay-at-home orders, school and venue closures, and workplace restrictions adopted at the national, state, and local levels. In addition to these

public health interventions, development of herd immunity could also provide a defense against COVID-19. However, whether immunity occurs among individuals after they have recovered from COVID-19 is uncertain. Many human infections with other viral pathogens, such as influenza virus, do not produce a durable immune response.

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