Effects of Candesartan vs Lisinopril on Neurocognitive Function in Older Adults With Executive MCI

Ihab Hajjar, MD, MS1,2; Maureen Okafor, MD, MPH1; Darius McDaniel, MS1; et al

JAMA Netw Open. 2020;3(8):e2012252. doi:10.1001/jamanetworkopen.2020.12252

Key Points

Question What are the comparative neurocognitive effects of an angiotensin receptor blocker, candesartan, and an angiotensin-converting enzyme inhibitor, lisinopril, on adults with hypertension and executive mild cognitive impairment?

Findings In this randomized clinical trial of 176 adults with hypertension, 12-month treatment with candesartan was associated with improvement in executive function and episodic memory compared with lisinopril.

Meaning These findings suggest that among older adults with hypertension and mild cognitive impairment, treatment with candesartan provided better neurocognitive effects compared with lisinopril despite equivalent blood pressure levels.

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