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Studies Suggest COVID-19 Vaccine Boosters Save Lives

JAMA. 2022;327(2):115. doi:10.1001/jama.2021.23455

The results of 2 large studies comparing severe disease and death among individuals vaccinated against COVID-19 support a benefit of booster doses. Both studies were conducted in Israel, where BNT162b2 (Pfizer-BioNTech) boosters were introduced in July 2021.

One analysis included data from more than 840 000 vaccinated people aged 50 years or older, 90% of whom received a booster dose. The death rate was 0.16 per 100 000 persons per day in the booster group compared with 2.98 per 100 000 persons per day in the nonbooster group. The other study involved almost 4.7 million vaccinated individuals aged 16 years or older. Across age groups, COVID-19 cases and severe illness were substantially lower among those who received a booster, as were deaths among those aged 60 years or older who were boosted.

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