By Kelly Young
The World Health Organization recommends systemic corticosteroids to treat patients with severe and critical COVID-19. The guidance coincides with the publication of three randomized trials and a meta-analysis on corticosteroids in JAMA.
The WHO recommends 6 mg of dexamethasone orally or intravenously daily or 50 mg of hydrocortisone intravenously every 8 hours for 7 to 10 days in the most seriously ill patients.
The organization also suggests that corticosteroids not be used to treat patients with milder COVID-19, as they may increase mortality risk in these patients.
In the WHO-sponsored meta-analysis, researchers examined the results of seven trials of corticosteroids versus usual care or placebo among some 1700 critically ill COVID-19 patients. The 28-day mortality rate, the primary outcome, was significantly lower among corticosteroid users (32% absolute mortality for corticosteroids vs. 40% assumed mortality for controls).
Editorialists conclude: "These studies provide evidence and some hope that an effective, inexpensive, and safe treatment has been identified."
Read more here : https://www.jwatch.org/fw117002/2020/09/02/who-recommends-corticosteroids-severe-covid-19-after?query=pfwTOC&jwd=000101330404&jspc=FPG